Challenges in Research on the Pathophysiology of Smoke Inhalation Injury and Its Clinical Management
نویسندگان
چکیده
Smoke inhalation injury is a serious medical problem that increases morbidity and mortality after severe burns. However, relatively little attention has been paid to this devastating condition, and the bulk of research is limited to preclinical basic science studies. Moreover, no worldwide consensus criteria exist for its diagnosis, severity grading, and prognosis. Therapeutic approaches are highly variable depending on the country and burn centre or hospital. In this Series paper, we discuss understanding of the pathophysiology of smoke inhalation injury, the best evidence-based treatments, and challenges and future directions in diagnostics and management.
منابع مشابه
Pathophysiology of acute lung injury in combined burn and smoke inhalation injury.
In the U.S.A., more than 1 million burn injuries occur every year. Although the survival from burn injury has increased in recent years with the development of effective fluid resuscitation management and early surgical excision of burned tissue, the mortality of burn injury is still high. In these fire victims, progressive pulmonary failure and cardiovascular dysfunction are important determin...
متن کاملA histological study on the effects of aqueous extract of Althea officinalis on epithelial and submucosal mucocilliary system of rat trachea following inhalation of cigarette smoke
The contents of cigarette smoke (gaseous and solid phases) have been attributed to a variety of diseases in the respiratory and cardiovascular systems and have been associated with development of different types of cancers. In respiratory system, these compounds specially cause epithelial cell injury, and interfere with mucocilliary transport (MTC). Various parts of Althea officinalis (family M...
متن کاملA histological study on the effects of aqueous extract of Althea officinalis on epithelial and submucosal mucocilliary system of rat trachea following inhalation of cigarette smoke
The contents of cigarette smoke (gaseous and solid phases) have been attributed to a variety of diseases in the respiratory and cardiovascular systems and have been associated with development of different types of cancers. In respiratory system, these compounds specially cause epithelial cell injury, and interfere with mucocilliary transport (MTC). Various parts of Althea officinalis (family M...
متن کاملFocus on smoke inhalation--the most common cause of acute cyanide poisoning.
The contribution of smoke inhalation to cyanide-attributed morbidity and mortality arguably surpasses all other sources of acute cyanide poisoning. Research establishes that cyanide exposure is: (1) to be expected in those exposed to smoke in closed-space fires; (2) cyanide poisoning is an important cause of incapacitation and death in smoke-inhalation victims; and (3) that cyanide can act inde...
متن کاملAcute Cyallide poisoning
Web publication: 23 March 2006 Abstract The contribution of smoke inhalation to cyanide-attributed morbidity and mortality arguably surpasses all other sources· of acute cyanide poisoning. Research establishes that cyanide exposure is: (1) to be expected in those exposed to smoke in closed-space fires; (2) cyanide poisoning is an important cause of incapacitation and death in smoke-inhalation v...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره 388 شماره
صفحات -
تاریخ انتشار 2016